The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Barre DE. The leaves have been used to treat rheumatism, colds, and bronchitis, as well as to increase lactation in women. The effect of borage oil consumption on the composition of individual phospholipids in human platelets. A. Dietary fatty acid modulation of mucosally-induced tolerogenic immune responses. View abstract. Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Pyrrolizidine alkaloids. Rosenstein, E. D., Kushner, L. J., Kramer, N., and Kazandjian, G. Pilot study of dietary fatty acid supplementation in the treatment of adult periodontitis. Fisher BAC, Harbige LS. The safety of evening primrose oil in epilepsy. What you eat can have a big effect on inflammation in your body. Prostaglandins Leukot Essent Fatty Acids 1994;51:311-6. Infant formula supplemented with fatty acids from borage oil and fish oils seems to improve growth and development of the nervous system in infants born early, especially boys. Though eczema is commonly treated with medicated creams, oral drugs, and even injections, some people desire a more natural way to relieve their…. Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with BORAGE. Bamford JTM, Ray S, Musekiwa A, et al. That said, remember that supplements are not regulated by the FDA. 6-16-2006;110(2):212-216. View abstract. View abstract. GLA is the part of borage seed oil that might slow blood clotting. As a type of polyunsaturated fatty acid (PUFA), GLA found in … The Herb Borage (Borago officinalis) – ©The Herbal Resource The plant has also its traditional external uses. WHO working group. Fundam.Clin.Pharmacol. Available at: https://www.cfsan.fda.gov/~dms/dspltr06.html. J Ren Nutr 2005;15(3):318-331. Lipids 1992;27(5):315-320. Borage supplements may cause mild side effects, including digestive problems. Adv Pharmacol Sci. Acta Derm.Venereol 1993;73(1):18-20. © 2005-2020 Healthline Media a Red Ventures Company. Nutr Cancer 1995;24:33-45. . Taking borage seed oil along with medications that also slow clotting might increase the chances of bruising and bleeding. Boarge oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha. Borage is an annual plant that is native to the Mediterranean region but has been widely naturalized in other areas. Oral evening primrose oil and borage oil for eczema. Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Prostaglandins Leukot.Essent.Fatty Acids 2003;68(3):213-218. However, it’s unclear whether borage specifically was responsible for the beneficial effects observed in these studies. J Nat Prod 1984;47:747-8. View abstract. View abstract. Treatment of rheumatoid arthritis with gammalinolenic acid. There is some evidence that borage seed oil, when taken by mouth in combination with eicosapentaenoic acid (EPA), might reduce the number of days spent in the intensive care unit (ICU) and the length of time a breathing machine is needed by patients with acute respiratory distress syndrome (ARDS). Another 12-week study in 43 children found that taking a supplement containing borage oil, along with a blend of other ingredients like fish oil, vitamins, and minerals, decreased inflammation and symptoms of asthma (10). Be sure to tell your doctor what natural products you are taking before having surgery. Another review of 13 studies turned up mixed results regarding the effectiveness of borage oil for atopic dermatitis, but it noted that the majority of studies showed it may be somewhat beneficial for treating its symptoms (13). Pediatr Dermatol 1997;14:423-5. Borage leaves have been used as a potherb and in European herbal medicine since the Middle Ages. Taking borage seed oil by mouth does not seem to improve eczema in adults or children. View abstract. According to one test-tube and animal study, borage seed oil was found to protect against oxidative cell damage, which could contribute to inflammation (7, 8). Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Engler MM, Engler MB, Erickson SK, Paul SM. Some NSAIDs include ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene), aspirin, and others. Fan YY, Chapkin RS. View abstract. Our website services, content, and products are for informational purposes only. Borage seed oil 1 to 3 g/day has been given in clinical trials (1 g/day has been used in children, and up to 3 g/day has been used in adults). GLA is an omega-6 fatty acid found in evening primrose oil. The leaves are edible and the plant is grown in gardens for that purpose in some parts of Europe. Additionally, borage has been reported as the likely cause of several cases of a blood disorder in infants in Europe. Borage may also lower the seizure threshold and should not be used with drugs that can also have this effect, such as tricyclic antidepressants and phenothiazines. Potential of evening primrose, borage, black currant, and fungal oils in human health. Rossetti, R. G., Seiler, C. M., DeLuca, P., Laposata, M., and Zurier, R. B. Studies show that borage may help alleviate inflammation, reduce symptoms of asthma, and improve skin health. Growth and development in premature infants. Those with liver issues and women who are pregnant or breastfeeding should avoid borage. Infusions of the leaves have been used to induce sweating and urination. Borage seed oil might interact with medications used during surgery. View abstract. Martens-Lobenhoffer, J. and Meyer, F. P. Pharmacokinetic data of gamma-linolenic acid in healthy volunteers after the administration of evening primrose oil (Epogam). CONDITIONS OF USE AND IMPORTANT INFORMATION: Eur J Clin Nutr 2000;54:234-8. Dooper, M. M., van Riel, B., Graus, Y. M., and M'Rabet, L. Dihomo-gamma-linolenic acid inhibits tumour necrosis factor-alpha production by human leucocytes independently of cyclooxygenase activity. A dental condition called periodontitis. Tollesson A, Frithz A. Borage oil, an effective new treatment for infantile seborrhoeic dermatitis. View abstract. Borage is an herb that has long been prized for its health-promoting properties. You can also find softgel supplements at many health stores and pharmacies, typically in doses ranging from 300–1,000 mg. Loose-leaf or prepackaged teas are available as well, which can be steeped in hot water to make a soothing cup of borage tea.
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