J. Pharmacol. (1948) Toxicological investigations of compounds proposed for use as insect repellents. Beta adrenergic blockers: SAR of beta blockers, Propranolol*. Ann. Food Chem. (1964) A comparison of the toxicity of some allyl, propenyl, and propyl compounds in the rat. 10), 1–35. & Sugimoto, K. (1987) SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: Examination with 151 chemicals. Introduction and study of different equipments and processing, e.g., B.O.D. 859). 4. Hyg. A group ADI of 0–5 mg/kg bw was confirmed by the Committee at its forty-sixth meeting (Annex 1, reference 122) and maintained at the present meeting. & Willis, B.J., eds, Flavors and Fragrances: A World Perspective. 250 Unpublished report No. Emulsions and theories of emulsification, microemulsion and multiple emulsions; Stability of emulsions, preservation of emulsions, rheological properties of emulsions and emulsion formulation by HLB method. 460 National Toxicology Program (1990) Toxicology and carcinogenesis studies of benzaldehyde in F344/N rats and B6C3F1 mice (gavage studies) (NTP-TR-378; NIH Publication No. (1983) 13 weeks Pharmacology of drugs acting on central nervous system. Toxicol., 10, 637–647. Therefore, these three substances were considered to be of no safety concern of the current levels of intake. Of the 37 substances in this group, 29 have been reported to occur naturally in foods. Environ. This site uses Akismet to reduce spam. 840), were to be consumed simultaneously on a daily basis, the estimated combined intake would exceed the human intake threshold for class I. Aldehyde & their derivatives: Triclofos sodium, Paraldehyde. Dillon, D.M., McGregor, D.B., Combes, R.D. The evaluation of these substances therefore proceeded via the left-hand side of the decision tree in the Procedure. Environ. Methyl benzoate (No. Program (1993) Gavage Int. Environ. Intake expressed as µg/kg bw per day calculated as follows: [(µg/person per day)/body weight], where body weight = 60 kg. 850) (Annex 1, reference 122). 841), benzyl benzoate (No. At autopsy, no treatment-related abnormalities were observed, and the weights of the livers and kidneys were within normal limits for both groups. (1988); Myhr et al. Learn how your comment data is processed. Food Cosmet. 25), benzyl acetate (No. Benzal glyceryl acetal. Dermal toxicity in rabbits. Toxicol. (1990) L5178Y mouse lymphoma cell mutation assay results with 41 compounds. McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C. & Caspary, W.J. • The dashed lines inside the hexagon in the resonance hybrid of benzene indicate that the π-electrons are delocalized and shared equally by all 6 C’s. coal distillate cherries, peaches and almonds Tolu balsam Mutag., 5, 482 (Abstract Ef-5). 13 weeks National Toxicology Toxicology, 9, 257 (Abstract 1031). & Wenk, M.L. A 4-generation study in rats showed no effect on growth, fertility, lactation or survival". Determination of Fiber length and width, 6. Determination of viscosity of semisolid by using Brookfield viscometer. Gavage Program (1986) Program (1986) Hyg. Ring Analogues of Phenothiazeines: Chlorprothixene, Thiothixene. Submitted to WHO by Flavor and Extracts Manufacturers Association of the United States. National Toxicology However, in Northern Ireland (which is part of the United Kingdom) M. Pharm degrees (as opposed to BSc or B. Pharm degrees) are offered at Queen’s University Belfast as in the rest of the UK. Further data on these four flavouring agents and the results of studies with eight other benzyl derivatives in the group (Nos 24, 841, 842, 851, 857, 864, 867, and 868) are presented in Table 6. The results of a series of long-term studies of toxicity and carcinogenicity in mice and rats (Kieckebusch & Lang, 1960; Marquardt, 1960; Shtenberg & Ignat’ev, 1970; Toth, 1984; Abdo et al., 1985; National Toxicology Program, 1986, 1989, 1990, 1993) with four representative benzyl derivatives, benzyl alcohol (No. Exp. Edible vaccines. (1973) Synergistic toxicity of official permissible preservative food additives. Males at the highest dose had an increased relative liver weight. Mutat. 22), benzyl acetate (No. Sado, I. The remaining alcohol or acid components formed by hydrolysis are simple aliphatic substances that are either oxidized to polar, excretable metabolites or metabolized in the fatty acid pathway and tricarboxylic acid cycle. Pharmacology of drugs acting on peripheral nervous system. Induction of SCE by some phenolic and related constituents derived from cigarette smoke: A study of structure–activity relationships. Agents with mixed mechanism: Ephedrine, Metaraminol. mucilages, oleoresins and oleo- gum -resins). Davison, C. (1971) Salicylate metabolism in man. Appl. (1990) Investigations into the metabolism of cinnamic acid, cinnamyl alcohol and cinnamaldehyde in relation to their safety evaluation. Mutag., 7, 677–702. II. drug receptors interactions signal transduction mechanisms, G-protein–coupled receptors, ion channel receptor, transmembrane enzyme linked receptors, transmembrane JAK-STAT binding. At its forty-sixth meeting, the Committee evaluated the five benzyl derivatives as a group and maintained the group ADI of 0–5 mg/kg bw as benzoic acid equivalents (Annex 1, reference 122). 1/5 Environ. Benzyl butyrate (No. (1989) An evaluation of food flavoring ingredients in a genetic toxicity screening battery.

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